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Retatrutide (a triple GIP/GLP-1/glucagon receptor agonist), survodutide, mazdutide, and CagriSema represent the next generation of anti-obesity compounds that may offer even greater efficacy or better tolerability profiles

Comparison with AOD-9604 AOD-9604 is a modified version of Fragment 176-191 with an additional N-terminal tyrosine residue

comparisons Retatrutide vs Semaglutide: Triple vs Single Agonist Phase 2 trials reported 24.2% weight loss for retatrutide vs 14.9% for semaglutide in STEP 1 but only one is FDA-approved

This may be due to the increased functionality of reproductive organs, decreased homocysteine toxicity, and many other key factors

Pediatric use: Indications and dosage guidelines for children use, have been established over 15 years

A., & Kiel, D